| Episode | Airdate | Title |
|---|---|---|
| 401 | September 23, 2007 | He Loves to Fly and He D'ohs |
| 402 | September 30, 2007 | Homer of Seville |
| 403 | October 7, 2007 | Midnight Towboy |
| 404 | October 14, 2007 | I Don't Wanna Know Why the Caged Bird Sings |
| 405 | November 4, 2007 | Treehouse of Horror XVIII |
| 406 | November 11, 2007 | Little Orphan Millie |
| 407 | November 18, 2007 | Husbands and Knives |
| 408 | November 25, 2007 | Funeral for a Fiend |
| 409 | December 16, 2007 | Eternal Moonshine of the Simpson Mind |
| 410 | January 6, 2008 | E Pluribus Wiggum |
| 411 | January 27, 2008 | That 90's Show |
| 412 | February 17, 2008 | Love, Springfieldian Style |
| 413 | March 2, 2008 | The Debarted |
| 414 | March 9, 2008 | Dial 'N' for Nerder |
| 415 | March 30, 2008 | Smoke on the Daughter |
| 416 | April 13, 2008 | Papa Don't Leech |
| 417 | April 27, 2008 | Apocalypse Cow |
| 418 | May 4, 2008 | Any Given Sundance |
| 419 | May 11, 2008 | Mona Leaves-a |
| 420 | May 18, 2008 | All About Lisa |